Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation
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چکیده
منابع مشابه
Targeting Toll-like receptor 4 prevents cobalt-mediated inflammation
Cobalt-chrome alloy is a widely used biomaterial in joint replacements, dental implants and spinal rods. Although it is an effective and biocompatible material, adverse reactions to metal debris (ARMD) have arisen in a minority of patients, particularly in those with metal-on-metal bearing hip replacements. There is currently no treatment for ARMD and once progressive, early revision surgery of...
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Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial components. Triggering TLRs results in increased expression of multiple inflammatory genes, which then play a protective role against infection. However, aberrant activation of TLR signaling has a significant impact on the onset of cancer, allergy, sepsis and autoimmunity. Various adaptor proteins, inclu...
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ژورنال
عنوان ژورنال: ChemMedChem
سال: 2015
ISSN: 1860-7179
DOI: 10.1002/cmdc.201500188